Breaking Barriers to Mosquito RNAi Control: A dsRNA Biomanufacturing and Nanodelivery Platform for Sustainable Vector Management.
RNA interference (RNAi) offers a promising approach for pest control but is often limited by the instability of double-stranded RNA (dsRNA) and inefficient cellular delivery. We developed a biodegradable, redox-responsive polyaminoglycoside nanocarrier (SS-HPT) to improve dsRNA stability, cellular uptake, and intracell...