Jie Sun

Covalent Recruitment of E3 Ligases: A New Path for Rational Design of Protein Degraders.

The covalent recruitment of E3 ubiquitin ligases is a rapidly advancing strategy in targeted protein degradation (TPD). While traditional non-covalent PROTACs and molecular glues operate through transient binding equilibria that can limit catalytic efficiency, covalent degraders form irreversible bonds with E3 ligases,...