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Author

Jie Sun

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Sep 2026

Paternal glufosinate exposure alters early embryonic inflammatory signals and offspring neurobehavior in IVF-derived mice.

PURPOSE Glufosinate (GLA) is a widely used herbicide, but developmental risks from paternal preconception exposure are unclear. We tested whether paternal GLA exposure affects offspring neurobehavior via fertilization-stage transmission using IVF. RESULTS Male mice received GLA (0.2 mg/kg·day) for 10 weeks, and sperm...

Zhi-Lu Pei, Da-Yu Hu, Tong Zhang et al. · 0 citations
Open access Aug 2026

Unconventional role of hydroxymethylglutaryl-CoA synthase 1 in driving pathogenic TH17 cell immunity and autoimmune diseases

This work unveils a noncanonical axis in which HMGCS1 sustains ER stress to license pTH17 differentiation during autoimmune responses, and thereby unveils a noncanonical axis in which pTH17 immunity and mitigates autoimmune disease in vivo are revealed.

Jie Sun, Ya-Li Lei, Huan-Huan Yang et al. · 0 citations

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