Open access
Oct 2026
SENP3-mediated deSUMOylation of PINK1 suppresses mitophagy and aggravates lipopolysaccharide-induced acute lung injury
Mitochondrial dysfunction triggers excessive reactive oxygen species (ROS) accumulation, which greatly exacerbates acute lung injury (ALI). Mitophagy, a cellular mechanism for maintaining mitochondrial homeostasis, is crucial to the progression of ALI. SENP3 is a redox-sensitive SUMO2/3 protease that is pivotal i...
Shuang-Jun He, Chen-Yu Fan, Chun-Yan Guo et al.
· Respiratory Research · 0 citations