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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Jieqiong Lou

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2 papers indexed here

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Open access Sep 2026

SMCHD1’s DNA binding activity enables its stable retention on chromatin

Chromatin proteins play critical roles in gene regulation, yet frequently we do not fully understand how weak DNA binding affinity of such proteins contributes to their locus-specific actions. Here, we studied SMCHD1, a non-canonical SMC-family protein involved in three-dimensional genome organization and gene repressi...

Rui-Feng Hu, Julissa J. Sánchez-Velásquez, Jieqiong Lou et al. · 0 citations
Open access Sep 2026

Cell cycle dependent regulation of mRNA export in response to replication stress

Nuclear export of mRNA is extensively coupled to transcription and processing of mRNA. How mRNA export is mechanistically regulated remains poorly understood. Here, we uncover a physical checkpoint at nuclear speckles that regulates mRNA export during DNA replication in S-phase of the cell cycle. Unbiased screening app...

Tobias D. Williams, Kirstyn T. Carey, W. Hamilton et al. · 0 citations

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