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Author

Jiffin Paulose

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Sep 2026

Melatonin, circadian metabolism, mitochondrial remodeling, and cell size dynamics in primitive hematopoietic stem cells.

Primitive hematopoietic stem cells (pHSCs) sustain lifelong hematopoiesis through tightly regulated transitions between quiescence and activation. Circadian oscillations influence hematopoiesis; however, the mechanisms coordinating metabolic state and stem cell function daily remain incompletely defined. Here, we show...

Priyasmita Chakrabarti, Abhishek K. Singh, Nicola K. Wilson et al. · 0 citations
Open access Jul 2026

A patient-derived mouse model reproduces molecular, neurological, and sleep symptoms of SHINE syndrome.

A mouse model of SHINE syndrome carrying the patient-derived DLG4V692Wfs*12/+ variant associated with a severe form of the disorder is developed and characterized, establishing Dlg4V692Wfs*12/+ mice as a robust and translationally relevant model that reproduces key molecular and behavioral features of SHINE syndrome.

Sharon Tamir, Jiffin Paulose, A. Nguyen et al. · 0 citations

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