Jihyeon Yeo

Diastereoselective synthesis of substituted cyclopentanones via [3 + 2] cycloaddition of sulfoxonium ylides with alkenes

We report a straightforward one-step, highly diastereoselective [3 + 2] cycloaddition for the synthesis of cyclopentanones incorporating up to four stereogenic centres. Sulfoxonium ylides are readily available, safe-to-use reagents and were utilised as three-carbon synthons to introduce alkyl, aryl, and heteroatom subs...