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Author

Jim Baggen

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Open access Aug 2026

Unravelling resistance mechanisms of oncolytic viruses in glioblastoma

Glioblastoma (GBM) is an aggressive primary brain tumor with a major unmet medical need. Oncolytic viruses (OVs) show promise for GBM treatment, but complete remissions remain rare. The intratumoral heterogeneity of GBM drives therapeutic escape and emergence of OV-resistant subclones. Beyond the well-characterized int...

T. Deconinck, T. Dierckx, F. De Smet et al. · 0 citations

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