Marine phlorotannins block SARS-CoV-2 entry via ACE2 and attenuate pulmonary inflammation in K18-hACE2 transgenic mice.
SARS-CoV-2 has transitioned from pandemic to endemic circulation, yet it continues to cause severe respiratory disease, particularly in vulnerable populations. Effective antivirals with well-defined mechanisms of action remain a critical unmet need. Marine phlorotannins are structurally complex polyphenols from edible...