Author

Jin-A Lee

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Review Open access Mar 2026

Organelle-anchored translation factories: the roles of neuronal RNA-binding protein condensates in organizing local protein synthesis in neurological diseases

Abstract Neurons face a fundamental proteostasis challenge: synapses and axons located far from the soma must rapidly remodel their proteome during activity, stress, and development. While local protein synthesis has long been recognized as essential for meeting these demands, classical models largely focused on ribonu...

Semin Park, Hari Lim, Jin-A Lee · Protein & Cell · 0 citations

Open access Aug 2026

Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammation

The TAM receptor AXL is identified as a molecular transducer that couples Aβ sensing to the regulation of autophagy and neuroinflammation in astrocytes and proposed the AXL-ICD/SIRT2 axis as an effective therapeutic target to reduce Aβ burden and neuroinflammation in AD.

T. Kim, Mridula Bhalla, Uiyeol Park et al. · bioRxiv · 0 citations

Open access Jul 2026

Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer’s disease

QA activates a microglia-specific signaling cascade that promotes PE biosynthesis and GAP, thereby enhancing Aβ clearance and mitigating AD pathology, and reveals a paradoxically beneficial role of QA in activating a microglia-specific signaling cascade that promotes PE biosynthesis and GAP.

Seung Jae Hyeon, Seungchan Kim, Jiyeon Chu et al. · Signal Transduction and Targ... · 2 citations