Jin-Hai Yu

Discovery of novel pyrazolo[3,4-d]pyrimidine-6-amine derivatives as potent polo-like kinase 2 inhibitors.

The design and synthesis of novel PLK2 inhibitors, featuring pyrazolo[3,4-d]pyrimidine derivatives, are reported, establishing pyrazolo[3,4-d]pyrimidine derivatives as promising PLK2 inhibitors with strong therapeutic potential for colorectal cancer.