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AI demonstrates promising performance for automated WMH segmentation, with U-Net–based architectures showing superior accuracy, however, substantial heterogeneity highlights the need for standardized imaging protocols and robust external validation.
Background Alzheimer’s disease (AD) and vascular dementia (VaD) have become significant global health challenges. Recent research evidence indicates a close comorbidity between AD and cerebral small vessel disease. The C677T (rs1801133, also known as c.665C > T) and A1298C (rs1801131) polymorphisms in the methylenetetr...
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