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5-fluorouridine is identified as a promising antifungal candidate and C-5-halogenated nucleosides are established as a privileged scaffold for antifungal drug development.
Findings indicate that multi-halogenated benzophenones act primarily as anti-virulence agents targeting biofilm formation and hyphal development and identify benzophenone scaffolds as promising leads for developing novel antibiofilm strategies against azole-resistant Candida infections.
Low toxicity in plant, nematode, and mammalian models highlights bioisosteric N-acyl sulfonamides as promising antivirulence scaffolds for combating S. aureusBiofilm-associated Staphylococcus aureus infections remain difficult to treat using conventional antibiotics.
It is demonstrated that a dihalogenated indole reduces lipase-associated virulence related phenotypes in C. acnes and suppresses biofilm formation in skin-relevant environments, supporting further investigation of this scaffold as a therapeutic strategy targeting acne-associated microbial physiology.
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