Open access
Sep 2026
Betaine-driven Keap1 methylation promotes p62-mediated autophagy and Nrf2 stabilization to alleviate glutathione-dependent redox dyshomeostasis in liver injury
Evidence is provided that betaine (trimethylglycine; BET) can regulate the Keap1-Nrf2 axis through modulation of Keap1 and that Keap1 cysteine methylation may represent a regulatory node linking betaine to p62-mediated autophagy, Nrf2 stabilization, and GSH homeostasis.
Moon-Han Chang, Chae Hwan Lee, Yeongrae Cho et al.
· Molecular Biomedicine · 0 citations