Author

Jin-Jian Guo

2 papers indexed here

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Open access Sep 2026

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

ABSTRACT Atherosclerotic cardiovascular disease (ASCVD) remains the leading global cause of mortality, with substantial residual inflammatory risk persisting despite statin therapy. We identify a c‐Rel‐driven CD72hi macrophage subset markedly enriched in human and murine atherosclerotic plaques, whose abundance correla...

Xing-Ling He, Si-Jing Li, Jia-Hui Chen et al. · Advancement of science · 0 citations

Open access Sep 2026

Disrupted thyroid hormone–mitochondrial coupling in diabetic cardiomyopathy: a candidate upstream amplifier of metabolic and redox maladaptation

Diabetic cardiomyopathy (DCM) is characterized by mitochondrial metabolic inflexibility, redox imbalance and defective organelle quality control, yet the endocrine program coordinating these abnormalities remains incompletely defined. Thyroid hormone (TH) is a major regulator of cardiac energy metabolism and mitochondr...

Ye-Bin Xia, Wen-Jie Zhang, Jin-Jian Guo · Frontiers in Endocrinology · 0 citations