TCR Signal Strength and Duration In Primary Mouse CD8+ T Cell Activation and Differentiation: A Standardized In Vitro Approach.
T cell receptor (TCR) signal intensity and duration are critical determinants of CD8⁺ T cell activation, proliferation, and functional differentiation. However, standardized in vitro models that systematically compare how varying TCR signal inputs shape T cell fate remain limited. This study presents a reproducible met...