Open access
Aug 2026
NF-κB-driven immune checkpoint knockdown and cytokine expression in cancer cells for tumor immunotherapy
A tumor-selective, safe therapeutic gene cassette specifically activated by NF-κB to produce cytokine IL-15 and microRNAs silencing two key immune checkpoints, PD-L1 and CD47, is constructed and shows significant antitumor effects, favorable tumor selectivity, and biosafety across multiple murine solid tumor models.
Yi-Le Wang, Zi-Yan Kong, Yun-Qi Zhao et al.
· iScience · 0 citations