Author

Jin Li

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Open access Sep 2026

An H2A.Z-dependent epigenetic checkpoint in macrophages couples genetic risk to microbial metabolite signaling.

Inflammatory gene programs must be precisely controlled to maintain immune homeostasis, yet the chromatin mechanisms enforcing transcriptional shutdown remain unclear. Here we show that the histone variant H2A.Z is evicted from pro-inflammatory loci upon acute macrophage activation and re-deposited during resolution. M...

Zhao-Ran Sun, Fan-Yi Meng, Chun-Jian Piao et al. · Protein & Cell · 0 citations

Open access Aug 2026

Shared genetic architecture and therapeutic targets across paediatric immune-mediated diseases.

OBJECTIVES Paediatric-onset immune-mediated inflammatory diseases (IMIDs), including juvenile idiopathic arthritis and related rheumatic diseases, remain genetically undercharacterised. We aimed to define shared and category-specific genetic architecture across paediatric IMIDs, compare signals with adult IMIDs, and id...

Jin Li, Hui-Qi Qu, Michael E. March et al. · Annals of the Rheumatic Dise... · 0 citations