Trichostatin A ameliorates ulcerative colitis via the SERPINB5-mediated MMP9/RLN2 signaling pathway.
OBJECTIVE To identify the key molecular target and elucidate the underlying mechanism by which the histone deacetylase inhibitor trichostatin A (TSA) treats ulcerative colitis (UC). METHODS Murine UC models were established via chronic cyclic dextran sulfate sodium (DSS) administration (2.5% DSS for 5 days, followed...