Di-2-ethylhexyl phthalate (DEHP) accumulates in the food chain, threatening human and animal health. However, how DEHP induces neurotoxicity by interfering with microglia has not been fully revealed. Our research aims to explore the effects of DEHP on microglia and identify relevant targets that cause neurotoxicity....
Ying-Xin Zhao, Ke-Tian Zhu, Yu-Xuan Tong et al.· Journal of Agricultural and...· 0 citations
Di(2-ethylhexyl)phthalate (DEHP), a common environmental endocrine disruptor and agricultural organic pollutant, has drawn wide concern for its hepatotoxicity. However, the molecular mechanisms underlying DEHP-induced hepatic fibrosis remain unclear. Through network toxicology analysis, lipid metabolism and autophagy...
Hao Zhang, Jia-Jing Cui, Jia-Xin Wang et al.· Journal of Agricultural and...· 0 citations
It is indicated that disruption of MFN2-dependent ER-mitochondria communication promotes OTA-induced ferroptosis by impairing mitophagy and identify MFN2 as a potential target for mitigating mycotoxin-associated liver injury.
Zi-Yan Hu, Rui-Qi Liu, Yu-Xuan Ouyang et al.· Journal of Hazardous Materia...· 0 citations
This study uncovers a CDK4/MERCs/PINK1 axis mediating PFOA/HFPO‐TA‐induced myocardial toxicity and identifies CAG as a promising natural product for mitigating environmental pollutant‐induced cardiac senescence, offering insights for PFAS health risk assessment and intervention strategies.
Nuo-Wa Li, Junze Jiang, Ying-Ying Liu et al.· Advancement of science· 0 citations
It is demonstrated that DEHP/MEHP disrupts the lipid metabolism regulated by MAM through a GRP75-dependent mechanism, thereby leading to liver steatosis.
Hao Zhang, Jia-Jing Cui, Bing Sun et al.· Food Science and Human Welln...· 0 citations
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