The pathogenesis of osteoarthritis (OA) has remained unclear, posing a clinical challenge. Although SRY-box transcription factor 9 (SOX9) has been reported to inhibit OA progression, the specific mechanisms through which it regulates inflammation in OA, especially with respect to chondrocyte autophagy, remain poorly un...
Jun Qin, Zai-Nen Qin, Ke Ma et al.· International Journal of Bio...· 0 citations
Marine-derived compounds represent an important source of innovative therapeutics owing to their structural diversity and broad bioactivity; however, their potential in osteoporosis therapy remains insufficiently explored. This study investigated the effects of plitidepsin (Pli), a marine-origin cyclic peptide, on os...
Jin-Deng Liao, Liang Liao, Qiu-Fei Li et al.· Scientific Reports· 0 citations
The results suggest that CVB suppresses osteoclastogenesis and their resorptive function through modulation of MAPK and PI3K/AKT/FOXO1 pathways and by enhancing antioxidant defense, which has potential therapeutic value for antiosteoporosis treatment.
Qiu-Fei Li, Na Hai, Jin-Deng Liao et al.· Journal of Agricultural and...· 0 citations
A novel functionalized 3D-printed scaffold with NIR-II responsiveness (BGS/I-LDH@MgO2), designed to simultaneously address the dual needs of inhibiting osteosarcoma recurrence and promoting bone regeneration, demonstrates excellent anti-tumor and osteogenic properties.
Hong Cheng, Tao Wang, Hanji Huang et al.· Bioactive Materials· 0 citations
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