B7−H3 is widely expressed in multiple solid tumors but shows minimal expression in normal tissues, making it an ideal target for molecular imaging; however, its systematic investigation remains limited. In this study, we utilized the clinically investigated B7−H3-targeted antibody−drug conjugate (ADC) HS-20093 to dev...
Jia-Yu Sui, Jing-Jie Qin, Jessica C. Hsu et al.· Molecular Pharmaceutics· 0 citations
Circulating cell-free DNA (cfDNA) has attracted increasing attention as a minimally invasive biomarker for assessing radiation-induced tissue injury. Radiation exposure can alter cfDNA concentration, fragmentation profiles, and methylation patterns. These changes may reflect cellular damage, tissue origin, and temporal...
Qi-Xin Sun, Yi-Kun Li, Tian-Wen Yin et al.· Cancer Metastasis Review· 0 citations
The core biological functions of FAP-expressing fibroblasts in disease pathogenesis are delineated, and the rapid advancement of radionuclide-labeled FAPIs are systematically examined, including optimization of linkers, chelators, and albumin-binding moieties, along with multimerization strategies, which significantly...
Jie Liu, Xinzhi Zhao, Pei-Fei Liu et al.· Accounts of Chemical Researc...· 0 citations
A snoRNA-chromatin-repair axis driving therapeutic resistance and support SNORA23 inhibition as a promising strategy to overcome radioresistance in ESCC are defined.
Bao-Qing Tian, Hua Zhang, Jiao Ren et al.· Cell Death and Differentiati...· 0 citations
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