PIEZO1 promotes YAP/TEAD-dependent profibrotic signaling in POSTN-enriched lung fibroblast activation.
Idiopathic pulmonary fibrosis (IPF) is driven by persistent fibroblast activation, excessive extracellular matrix (ECM) deposition, and progressive tissue stiffening, yet the mechanosensitive signaling programs that sustain fibrotic fibroblast states remain incompletely defined. Here, we investigated the association be...