Review
Open access
Sep 2026
Organelle-centered ISG15 biology: distinguishing covalent ISGylation from interferon-associated responses
Emerging evidence supports an organelle-centered view of ISG15 biology but indicates that validated covalent mechanisms remain confined to selected substrates and contexts.
Zhuo-Er Li, Chunli Wang, Jin-Rong Zhang et al.
· Frontiers in Immunology · 0 citations