Jin-Rui Chen

The HCMV terminase as an antiviral target: structural insights, inhibitory mechanisms, and the era of letermovir

Human cytomegalovirus (HCMV) remains a major cause of morbidity and mortality in immunocompromised individuals and newborns worldwide. Current antiviral therapies mainly target the viral DNA polymerase, but their long-term clinical use is often constrained by toxicity and the emergence of drug-resistant strains. The ap...