Open access
Aug 2026
Maternal obesity programs offspring metabolic dysfunction via small extracellular vesicle-mediated epigenetic remodeling
It is shown that maternal circulating small extracellular vesicles crossed the placenta and delivered obesity-associated miRNAs to the fetal liver, with lasting consequences for insulin sensitivity in male offspring, and a transplacental sEV-miRNA-epigenetic axis is identified as a mediator of maternal obesity.
Hui-Chen Song, Dameng Li, Li-Na Ma et al.
· Nature Communications · 0 citations