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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Jin Wang

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Open access Sep 2026

Structural basis for differential inhibition of THIK1 by chemically related inhibitors

TWIK-related halothane-inhibited potassium channel 1 (THIK1) is a two-pore domain potassium (K2P) channel highly expressed in microglia that contributes to microglial homeostasis and neuroinflammatory responses. Pharmacological inhibition of THIK1 suppresses tonic K+ currents and attenuates NLRP3-dependent IL-1β releas...

Ran Zhang, Xiang-Yu Fang, Rui-Heng Zhang et al. · 0 citations

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