Genomic or transcriptomic sequencing guides the precision of cervical cancer (CC) diagnosis; however, the molecular profile of Asian patients remains poorly understood. We established a comprehensive multi-omics cohort comprising 112 tumor-normal adjacent tissue pairs from Chinese CC patients. Our integrated analysis r...
Tao Pan, Xu-Cui Zhuang, Ya Zhang et al.· PLoS Biology· 0 citations
Hereditary ataxias are clinically and genetically heterogeneous, which complicates clinical management, genetic counseling, and scientific research. Efficient molecular diagnosis is essential but requires molecular epidemiological considerations due to the variable genetic landscapes across regions and populations. In...
Jin-Yang Yu, Yi-Min Sun, Yi Dong et al.· Translational Neurodegenerat...· 0 citations
Q-space trajectory imaging (QTI) provides promising markers of tissue microstructure, but clinical translation requires shorter acquisitions, faster analysis, and more robust parameter estimation at high spatial resolution. To address these barriers, we trained a voxel-wise multilayer perceptron (MLP) to infer QTI-deri...
Oliver Gödicke, Jin-Yang Yu, F. Laun et al.· Magnetic Resonance Imaging· 0 citations
Fast dMRI protocols for obtaining rotational invariants of the cumulant expansion were paired with constrained weighted linear least squares (CWLLS) to stabilize the more fragile WLLS fit, yielding high-quality parameter maps at an online-ready computational cost.
Jin-Yang Yu, Oliver Gödicke, F. Laun et al.· 0 citations
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