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Open access Sep 2026

SCO‑792 alleviates HFD‑aggravated chronic pancreatitis by modulating the gut–pancreas axis via the AMPK/ACC and TLR4/NF‑κB signaling pathways

Background Chronic pancreatitis (CP) is an inflammatory disorder that manifests as pancreatic fibrosis and exocrine insufficiency, and premature activation of trypsinogen to trypsin. Enteropeptidase has emerged as a promising therapeutic target in CP due to its critical role in activating trypsinogen. The aim of this s...

Yan-Ru Kang, Ning-Ning Sun, Wei-Jie Yao et al. · 0 citations
Oct 2026

Sodium butyrate combined with ethanol-metabolizing Lactobacillus strains attenuates alcoholic liver disease by restoring gut-liver homeostasis.

Alcoholic liver disease (ALD) is characterized by hepatic lipid accumulation, inflammation, and intestinal barrier dysfunction, while limited effective pharmacological interventions remain currently available. This study investigated the protective effects of sodium butyrate (NaB), alone and in combination with newly i...

Fei-Yan Long, Jin-Yu Li, Yan-Ru Kang et al. · 0 citations

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