Open access
Nov 2026
MultiMHC: a multiscale learning framework integrating sequence and residue contact topology for peptide–MHC binding prediction
Abstract Accurate prediction of peptide–major histocompatibility complex (pMHC) binding is central to understanding antigen presentation and identifying T-cell epitopes in cancer immunotherapy. Although recent methods have achieved notable progress, most approaches rely predominantly on sequence-based features and only...
Wen-Fan Chen, Ying Chi, Yi-Hao Wang et al.
· Briefings in Bioinformatics · 0 citations