Author

Jing Han

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Open access Sep 2026

An mPFC-DMV cortical-autonomic-immune axis governs stress-induced immune dysregulation in sepsis.

Chronic psychological stress is a major predisposing factor that worsens sepsis outcomes, yet the neural mechanisms linking stress exposure to immune dysregulation remain poorly understood. Here, using a mouse model of chronic restraint stress (CRS) followed by endotoxemia, we show that prior stress markedly aggravates...

Lu Yin, Fu-Hong Liu, Meng-Yun Li et al. · Molecular Psychiatry · 0 citations

Open access Sep 2026

Escalating demand for learning during adolescence impairs social interaction by hyperactivating midbrain dopamine neurons in young adulthood male mice.

Chronic stress during adolescence is a major risk factor for adult psychiatric disorders, yet the long-term impact of learning-related aversive stress remains poorly understood. This study established an mice model of learning demand stress by escalating the fixed ratio (FR) number of escape responses to foot shocks in...

Hao Wang, Fu-Hong Liu, Lin-Yuan Li et al. · Neurobiology of Disease · 0 citations