Author

Jing-Hong Wu

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Open access Sep 2026

The ribonuclease ZC3H12A stabilizes BRCA1 mRNA in DNA damage response.

ZC3H12A is an endoribonuclease that destabilizes target transcripts by recognizing stem-loop structures containing a pyrimidine-purine-pyrimidine loop. Here, we identify ZC3H12A as a constitutive stabilizer of BRCA1 mRNA that supports DNA repair capacity. Under basal conditions, depletion of ZC3H12A shortens the half-l...

Ming-Jun Lu, Jia-Bao Hou, Zhen-Dong Qin et al. · Redox Biology · 0 citations

Aug 2026

Pan-cancer single-cell atlas of immunotherapy response identifies ZNF385A as a regulator of immune evasion in small cell lung cancer.

Findings identify ZNF385A as a potential regulator associated with TLS deficiency and immune evasion in SCLC and a potential link between ZNF385A, genomic stability and tumor-intrinsic innate immune signaling.

Jia-Bao Hou, Xiao-Yue Zhu, Jing-Wei Guo et al. · Biochimica et Biophysica Act... · 0 citations