Author

Jing-Jing Liu

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Open access Oct 2026

Loss of transcriptional factor Zbtb33 fails to induce clonal hematopoiesis in mice but plays a role in tumor growth.

Clonal hematopoiesis (CH) is an early indicator of hematologic malignancies, driven by mutations in hematopoietic stem cells (HSCs) such as TET2 or P53. Recently ZBTB33 mutations have been implicated in myelodysplastic syndromes (MDS) and suggested as a driver of CH. However, the role of ZBTB33 in hematopoiesis and its...

Yu-Hang Li, Kai-Ping Luo, Ke-Yao Xia et al. · Disease Models & Mechanisms · 0 citations

Open access Sep 2026

GTPase RAB31 supports ANXA1-driven macrophage education through clathrin-mediated endocytosis to suppress antitumor immunity

Findings establish the CME/RAB31 pathway as an indispensable regulator of TAM polarization, underscoring the pivotal role of vesicular trafficking in the TME.

Jing-Jing Liu, Shan-Shan Wang, Deng-Yi Bao et al. · Journal for ImmunoTherapy of... · 0 citations