Inhibition of ERα in the mPFC ameliorates depression-like behaviors by suppressing GALR1-mediated synaptic dysfunction in an estrogen withdrawal-induced rat model.
Postpartum depression (PPD) is a major perinatal mood disorder closely associated with the abrupt decline in estrogen levels after childbirth. Galanin receptor1 (GALR1) is one of the receptors of galanin (GAL), which activates Gi-coupled inhibitory signaling and may play a pro-depression role. Our previous study showed...