Jing-Ke Zhang

Discovery and synthesis of 3-amino glycyrrhizin derivative containing guanidyl with anti-colorectal cancer activity.

Colorectal cancer is considered to be a highly immune-related disease, and the severe chronic inflammatory stress in the tumor microenvironment (TME) greatly impedes the effective prognosis and treatment of colorectal cancer. Based on a dual strategy, anti-proliferation and inhibition of inflammatory factor HMGB1, a se...