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Aug 2026

Class I capsid assembly modulators induce potent anti-HBV activity through direct viral suppression, innate immune activation and caspase-3-independent clearance of infected hepatocytes.

Capsid assembly modulators (CAMs) are promising antiviral agents for chronic hepatitis B virus (HBV) infection. This study investigates the anti-HBV activity and immunomodulatory effects of Class I CAMs (CAM-A) in vitro and in vivo. In HepAD38 cells, CAM-A treatment significantly upregulated the expression of interfero...

Pu-Shuo Wang, Xin-Chang Liu, Yong Xie et al. · 0 citations
Review Sep 2026

Platelet glycoprotein VI in platelet-neutrophil interactions: From complex formation to neutrophil extracellular trap-associated pathology.

Platelets and neutrophils form dynamic platelet-neutrophil complexes (PNCs) that connect vascular injury with inflammatory effector responses. Glycoprotein VI (GPVI), a platelet-restricted immunoreceptor, converts collagen- and fibrin-related cues into ITAM signaling, granule secretion and integrin activation. GPVI is...

Wei Xiong, Sheng-Tian Cao, Jing Li et al. · 0 citations

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