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Review Open access Sep 2026

Hypoxia-Induced Gut-Brain Axis Remodeling and Insomnia: Mechanisms and Microbiota Adaptive Regulation from a Translational Perspective

Abstract High-altitude hypoxia frequently disrupts sleep–wake cycles, causing insomnia that impairs acclimatization, performance, and health. Emerging evidence implicates the gut–brain axis (GBA) in this disorder. Prolonged or severe hypoxia can disturb intestinal epithelial homeostasis through oxidative, inflammatory,...

Huaxiucairang Yang, Wen-Guang Lan, Jing Liu et al. · 0 citations
Open access Oct 2026

Single-cell transcriptomic analysis reveals seed cells and microenvironmental crosstalk in gastric cancer peritoneal metastasis

Peritoneal metastasis is the most frequent and lethal metastatic pattern in gastric cancer, yet the identity of metastatic seed cells and the accompanying microenvironmental remodeling remain poorly defined. Integrated single-cell RNA sequencing analysis of cells derived from primary gastric tumors and peritoneal met...

Wei-Yi Chen, Ewetse Paul Maswikiti, Yi-Fan Li et al. · 0 citations

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