Self-oxygenating nanoreactors enable effective low-dose X-ray photodynamic immunotherapy against refractory tumors.
A new type of self-oxygenating nanoreactor (HCCP) is engineered to relieve hypoxia and effectively eradicate radio-resistant triple-negative breast cancer (TNBC) by combining low-dose X-ray-induced photodynamic therapy (LX-PDT), cuproptosis and chemodynamic therapy (CDT), which was further discovered to trigger the sti...