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Open access Oct 2026

Pharmacological inhibition of PRKDC-mediated DNA damage response by 3-hydroxyflavone selectively alleviates MLL-rearranged acute myeloid leukemia

Rearrangements of the mixed lineage leukemia (MLL) gene in acute myeloid leukemia (AML) have been associated with resistance to chemotherapy, and there is currently an unmet clinical need for effective targeted therapies. In this study, we performed high-throughput drug screening and identified 3-hydroxyflavone (3-...

Jing Liu, Chen-Xing Zhang, Min-Yi Zhao et al. · 0 citations
Review Oct 2026

A Community-centered Vision for Data-Intensive Great Lakes Research and Management

The Laurentian Great Lakes are a vital freshwater resource and a regionally significant natural system facing complex, persistent, and compounding challenges from climate change, nutrient loading, and invasive species. The increasing availability of observational data, coupled with advances in computational power and...

Dani Jones, Jing Liu, S. Steinschneider et al. · 0 citations

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