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Author

Jing-Meng Li

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Open access Sep 2026

Mechanisms of acquired resistance to osimertinib in EGFR T790M-Positive lung adenocarcinoma

Remarkable heterogeneity characterizes the resistance mechanisms emerging against osimertinib in EGFR T790M-positive lung adenocarcinoma, with EGFR secondary mutations, bypass signaling pathway activation, and histological transformation representing the primary categories.

Ke-Fan Cui, Ren-Jie Zhu, Jing-Meng Li · 0 citations

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