Open access
Aug 2026
Spatiotemporally programmed hybrid nano-prodrugs orchestrate multidimensionally synergistic cascade lethality in NSCLC
This findings demonstrate that E-R@ISSL achieved coordinated DNA damage, ferroptosis, and ICD induction through its dual-targeted and sequentially activated co-delivery of ETP and LA, concurrently dismantling the GSH/GPX4 antioxidant defense and intensifying oxidative injury.
Yan Wang, Chao-Zheng Zhang, Chen Sun et al.
· Theranostics · 0 citations