Open access
Sep 2026
Type I restriction–modification systems regulate gene expression through DNA topology
Abstract This study examines how DNA methylation by both phase-variable and canonical restriction–modification (RM) systems contributes to bacterial gene regulation, using the SpnD39III system of Streptococcus pneumoniae and the prototypical EcoKI system of Escherichia coli. RNA-seq analysis of pneumococcal phase-locke...
Yasmeen Althari, Yong-Kui Chen, A. Menon et al.
· Nucleic Acids Research · 0 citations