Review
Open access
Sep 2026
Regulatory roles of five key USP family deubiquitinases in cancer: from mechanisms to targeted therapy advances
Ubiquitination is a crucial post-translational modification of proteins in eukaryotic cells. Deubiquitinating enzymes (DUBs) remove ubiquitin molecules from substrate proteins, thereby reversing ubiquitination and maintaining intracellular ubiquitin homeostasis. Dysregulation or dysfunction of DUBs is closely associate...
Ya-Nan Wang, Jing Shi
· Frontiers in Pharmacology · 0 citations