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Review Sep 2026

Mitochondria-Endoplasmic Reticulum Contact Sites (MERCS/MAM): Multi-Layered Upstream Regulators of Microglial Senescence in Alzheimer's Disease.

BACKGROUND Alzheimer's disease (AD) is an age-dependent neurodegenerative syndrome in which microglial senescence bridges biological ageing and Aβ-tau pathology. Senescent microglia undergo permanent cell-cycle arrest, upregulate p16INK4a and SA-β-gal, and secrete a pro-inflammatory senescence-associated secretory phen...

An-Nan Liu, Li-Ping Xing, Jian-Hui Li et al. · 0 citations

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