Sep 2026
A novel mTORC1-NPC2 axis suppresses lipophagy and drives atherosclerotic plaque progression.
Hypercholesterolemia disrupts endothelial lipophagy through the mTORC1-NPC2 signaling axis, promoting lipid accumulation and accelerating atherosclerosis, and targeting this pathway may offer a novel therapeutic strategy for AS.
Le-Gao Chen, Wei-Qin Lu, Long Piao et al.
· Biochimica et Biophysica Act... · 0 citations