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Open access Oct 2026

Characterization of SPP1 + macrophages and their correlation with resistance to neoadjuvant chemotherapy in colorectal cancer liver metastasis

Neoadjuvant chemotherapy (NAC) for colorectal cancer liver metastasis (CRLM) remains a major clinical challenge, with outcomes varying widely among patients, yet the mechanisms that drive therapeutic resistance remain incompletely understood. In this study, we integrated single‑cell RNA‑sequencing and spatial transcrip...

Jing-Zhi Tang, Wei-Jie Hao, Xi-Gan He et al. · 0 citations
Open access Sep 2026

A Site‐Aware Representation Learning Framework For Unified Molecular Interaction Modeling and Generative Design

MolDBG achieves competitive performance across all three tasks while enabling site‐specific affinity prediction and interpretable binding‐site discovery, and generalizes to structurally elusive targets, including cryptic pockets and intrinsically disordered proteins.

Gang Luo, Qian-Qian Zhang, Chen-Hao Wang et al. · 0 citations

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