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Open access Sep 2026

Allotopic Expression of ND6 Restores Vision in a Mitochondrial Disease Model.

This study validates the safety and therapeutic potential of allotopic expression in vivo and provides critical mechanistic insights into its role in treating LHON and other mitochondrial diseases.

Cheng Ai, Hui-Ying Li, Jing Wu et al. · 0 citations
Review Open access Sep 2026

PERK signalling in neurodegenerative diseases: From ER stress to mitochondrial dysfunction and therapeutic opportunities

The PERK (PKR-like endoplasmic reticulum kinase) pathway is a key branch of the unfolded protein response (UPR), and is crucial for maintaining cellular homeostasis. In neurodegenerative diseases, factors such as misfolded protein accumulation and oxidative stress lead to sustained endoplasmic reticulum stress, thereby...

Tao Xu, Sheng-Wei Jing, Jing Wu · 0 citations

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