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Open access Sep 2026

Chemistry-informed Bayesian control and policy distillation for autonomous pH adjustment in diverse chemical systems

Adjusting pH of an arbitrary solution to a specified target remains difficult to automate when buffering behavior is unknown, nonlinear, and composition-dependent. We formulate pH adjustment as a sequential inference-and-control problem and develop a chemistry-informed Particle Filtering (PF) Bayesian controller that u...

Si-Yuan Zhang, Lin Huang, Tian-Ci Shi et al. · 0 citations
Sep 2026

Targeting the nonenzymatic scaffold function of RIPK1 via a VHL-recruiting PROTAC synergizes with immunotherapy in melanoma.

Receptor-interacting protein kinase 1 (RIPK1) mediates cell survival, inflammation, and cell death, and its kinase-independent scaffolding function drives tumor progression and therapeutic resistance, which cannot be eliminated by conventional RIPK1 kinase inhibitors. To overcome this limitation, we adopted proteolysis...

Shun-Xin Guo, Ming-Ze Tang, Pei Yu et al. · 0 citations

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