Jing-Yi Jiang

TRIM26 triggers ferroptosis via ZEB1 degradation to suppress nasopharyngeal carcinoma progression

SPATA2 Attenuates Inflammatory Injury Through CYLD-Related Regulation of Microglial Inflammatory Responses After Focal Cerebral Ischemia/Reperfusion in Rats.

BACKGROUND Post-ischemic inflammation is strongly influenced by interactions between neurons and microglia. We previously observed that spermatogenesis-associated protein 2 (SPATA2) alleviates inflammatory injury following cerebral ischemia/reperfusion; however, the relationship between SPATA2, cylindromatosis (CYLD)-a...

TNFAIP3 and MLKL-Related Necroptosis Signatures in Liver Transplant Ischemia–Reperfusion Injury: Integrated Transcriptomic and Experimental Evidence

Background and Aims Liver transplant ischemia–reperfusion injury (LIRI) is a major cause of early graft dysfunction. Necroptosis has been implicated in inflammatory tissue injury; however, its molecular characteristics and diagnostic relevance in LIRI remain unclear. This study aimed to identify necroptosis-related bio...

C1R suppresses hepatocellular carcinoma cell aggressiveness through promoting HIF-1α degradation and modulating cuproptosis-related protein expression.

A model in which C1R reduces aggressive phenotypes of HCC cells partly through destabilizing HIF-1α and reshaping copper-responsive processes is supported, which supports a model in which C1R reduces aggressive phenotypes of HCC cells partly through destabilizing HIF-1α and reshaping copper-responsive processes.