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Jing-Yi Yu

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#artificial intelligence Preprint Sep 2026

ProtLingo: Efficient Protein Language Modeling via Conditional Memory and Expert Routing

ProtLingo, an efficient PLM framework that augments a pretrained single-sequence backbone with conditional local memory and sparse expert routing, achieves competitive performance with a 150M-scale backbone, including strong parameter efficiency on mutation-effect prediction and preserved long-range structural represen...

Ming-Rui Li, Si-Xian Shen, Min-Zhang Li et al. · 0 citations

Jul 2026

Evolution-Aware MSA Reasoning for Subsampling via Factor Graphs

Experiments show that AP-REASONER outperforms baseline subsamplers on structure-sensitive downstream tasks and enables controllable recovery of alternative protein conformations, highlighting the value of modeling MSA subsampling as a controllable optimization problem, where factor-graph reasoning offers an effective a...

Zhangzhi Xiong, Min-Zhang Li, Hao Yu et al. · arXiv.org · 0 citations